Benjamin Mendy will not play this weekend and has not featured since knee surgery early in the season.
Raheem Sterling and Leroy Sane should both be recalled, while Pep Guardiola has hinted Kevin De Bruyne could be benched.
Vincent Kompany and Claudio Bravo remain sidelined, but otherwise Pep Guardiola has a full squad of players to pick from.
Possible Manchester City starting XI: Ederson; Walker, Stones, Laporte, Danilo; De Bruyne, Fernandinho, D. Silva; Sterling, Aguero, Sane
Chelsea manager Maurizio Sarri has no selection headaches before this game, in which he will deploy his strongest XI. He has said it is possible that Eden Hazard will play in a false 9 role.
Changes will be reserved for the Europa League encounter with Malmo in Sweden on Thursday.
Possible Chelsea starting XI: Kepa; Azpilicueta, Christensen, David Luiz, Alonso; Kante, Jorginho, Kovacic; Willian, Higuain, Hazard